Where does the difference in activity between the brand-name drug and the generic topiramate come from? The confidence interval makes it possible to judge the bioequivalence is tightened. The example of topiramate that you cite is one of the so-called "narrow therapeutic margin" drugs. These drugs are characterized by toxic or ineffective concentrations close to effective concentrations. Therefore, slight variations in dose or concentration may lead to a change in the benefit/risk ratio. In this logic, any change during treatment must be carried out with care, whether it involves switching from one originator to another, from one originator to a generic specialty, or from one generic thing to another. The dosage adjustment is sensitive for both the generic drug and the original drug. It should be noted that no proof has been provided to date that there is a risk in substituting drugs with a narrow therapeutic margin. Moreover, studies show that the risk of hospitalization for recurrence of epileptic seizures does not increase after covering an original drug by a generic. You can consult the results of these studies on the Effective and Safe Medicines page on the solidarites-sante.gouv.fr website.
Why are doctors more defiant than the general public and other healthcare professionals regarding generic drugs? Generic drugs have entered the practice of health professionals and physicians in particular. All physicians globally recognize their efficacy, safety, and quality. We observed during round tables held in the regions bringing together healthcare professionals and patients and organized in partnership with the College of General Medicine. Sure participants in the round tables nevertheless expressed the wish to clarify certain concepts: this is why practical information tools intended for doctors and pharmacists were developed at the end of these exchanges. They are available on the Medicines page of the solidarites-sante.gouv.fr site. The question/answer module also allows you to answer questions patients and prescribers may have about generic drugs. The BVA study of March 2016 also revealed that general practitioners generally have the same opinion as to the general public vis-à-vis generic drugs: 63% of doctors trust them - like 62% of French people as a whole and 96 % of pharmacists. In addition, 82% of doctors use generic drugs when they are sick, and 93% are satisfied with them, like the French (78% use them; 93% are satisfied) and pharma
Where does the difference in activity between the brand-name drug and the generic topiramate come from? The confidence interval makes it possible to judge the bioequivalence is tightened. The example of topiramate that you cite is one of the so-called "narrow therapeutic margin" drugs. These drugs are characterized by toxic or ineffective concentrations close to effective concentrations. Therefore, slight variations in dose or concentration may lead to a change in the benefit/risk ratio. In this logic, any change during treatment must be carried out with care, whether it involves switching from one originator to another, from one originator to a generic specialty, or from one generic thing to another. The dosage adjustment is sensitive for both the generic drug and the original drug. It should be noted that no proof has been provided to date that there is a risk in substituting drugs with a narrow therapeutic margin. Moreover, studies show that the risk of hospitalization for recurrence of epileptic seizures does not increase after covering an original drug by a generic. You can consult the results of these studies on the Effective and Safe Medicines page on the solidarites-sante.gouv.fr website.
Why are doctors more defiant than the general public and other healthcare professionals regarding generic drugs? Generic drugs have entered the practice of health professionals and physicians in particular. All physicians globally recognize their efficacy, safety, and quality. We observed during round tables held in the regions bringing together healthcare professionals and patients and organized in partnership with the College of General Medicine. Sure participants in the round tables nevertheless expressed the wish to clarify certain concepts: this is why practical information tools intended for doctors and pharmacists were developed at the end of these exchanges. They are available on the Medicines page of the solidarites-sante.gouv.fr site. The question/answer module also allows you to answer questions patients and prescribers may have about generic drugs. The BVA study of March 2016 also revealed that general practitioners generally have the same opinion as to the general public vis-à-vis generic drugs: 63% of doctors trust them - like 62% of French people as a whole and 96 % of pharmacists. In addition, 82% of doctors use generic drugs when they are sick, and 93% are satisfied with them, like the French (78% use them; 93% are satisfied) and pharma
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